Prepare
500mg prebiotic blend · psyllium husk + organic acacia gum
Psyllium produces short-chain fatty acids that maintain the gut lining. Acacia is gentle on sensitive guts.
The probiotic with ginger
The gut-hormone loop
Your mood lives in your gut.
About 90% of your body's serotonin, the calming brain chemical, is produced in your gut. Not in your brain. When the gut is off, your mood, your digestion, and your energy go with it.
- 89% said constipation improved*
- 87% said bloating improved*
- 86% said acid reflux improved*
*Self-reported after 3 months of daily use. Consumer perception study, n=40.
As seen in
You've been here a while
You did the work. You still don't feel like yourself.
You've cleaned up the sleep. Cut the sugar. Tried the gut reset, the elimination diet, the magnesium, the adaptogens, the probiotic everyone said to take.
Some of it helped a little. None of it explained why.
You knew something was off. You just couldn't name what.
The symptoms don't stack neatly. Bloating shows up with the mood crash. Brain fog rides the cycle.
You're not broken. The story you were given was incomplete.
This is for you if…
- Your mood and your gut feel like they’re moving together
- Bloating arrives with your period, your stress, or seemingly nothing
- Your energy dropped and you can’t pin it on sleep, food, or training
- Something about your hormones feels off and you can’t name what
- You tried a probiotic and felt a little better, or nothing at all
- A course of antibiotics threw something off, and it hasn’t fully come back
Three facts you weren't told together
Your gut runs your mood, your hormones, your nervous system.
Serotonin biology
~90%
of your body's serotonin is made in your gut, not your brain. When the gut is disrupted, mood follows.
Enteric nervous system
~500M
neurons line your gut wall. Your gut has its own nervous system, with more neurons than your spinal cord. It controls how things move, what you feel, and how the gut signals upward to your brain.
Hormone metabolism
The loop
Specific gut bacteria, the estrobolome, metabolize estrogen and recycle it back into circulation. When the estrobolome shifts, hormone metabolism shifts with it.
Most probiotics address none of this. Pre+Probiotic is built around it.
The gut-hormone loop
Your gut and your hormones are in constant conversation.
Hormones affect how your gut moves. Your gut affects how your hormones behave. When the conversation works, your digestion, cycle, mood, and energy hold together. When it breaks down, every system on the loop feels it.
The loop has two sides.
Gut
The gut microbiome, including the estrobolome (the bacteria that metabolize and recycle estrogen). Most probiotics address this side.
Brain
The enteric nervous system. The gut's nervous network, denser than your spinal cord, controlling motility, sensation, and upward signaling to the brain. Most probiotics ignore it entirely.
Pre+Probiotic supports both sides. Prebiotics and probiotics for the bacteria, standardized ginger for the nerves.
There's a layer underneath this loop that also matters: the daily nutrients your body uses to act on what the gut produces. We'll come back to that.
“For years I’ve struggled to find a pre/probiotic that agrees with my autoimmune and IBS issues. I’m very pleased with the results.”
What's in the bottle
Three layers. One system.
Populate
4 billion CFU · L. acidophilus + L. plantarum
L. acidophilus maintains the acidic environment that resists pathogens. L. plantarum actually survives GI transit.
Regulate
240mg standardized ginger extract · 5% gingerols
The layer most probiotics don't have. Gingerols and shogaols calm the enteric nervous system: the receptors behind cramping, bloating, and erratic motility.
Prebiotics prepare the soil. Probiotics populate it. Ginger regulates the environment they live in. None of the three works as well alone.
“I have lots of digestive issues. I tried this hoping it would help, IT DID. No more bloating, regulated by the second bottle.”
Why most probiotics underdeliver
The strains arrive. And most of them die.
Most probiotic products are strains in a capsule, with no consideration for the environment they land in. The microbiome they meet is often dysregulated, sometimes inflamed, not particularly hospitable. Establishment rates are low. Strains pass through.
Three things have to be true for a probiotic to do what it claims:
- The strains chosen for the biology you're supporting, not for what's cheapest to culture
- The environment prepared with the right fibers, so the strains have something to feed on
- The signaling system that controls gut motility calm enough for the strains to establish
Pre+Probiotic is built around all three. That's why we don't lead with the CFU count.
What the research shows
Three pieces of clinical research. Built into the formula.
Mechanism
The 5-HT3 mechanism
Gingerols and shogaols inhibit 5-HT3 receptors on the neurons lining your gut wall. Overactivated, these receptors drive cramping, nausea, and erratic motility. Ginger calms them at the source.
Hu et al., World Journal of Gastroenterology (2011) · Lakhan et al., Nutrition Journal (2015) · Lashgari et al., Biofactors (2022)
Strain research
L. plantarum survives the trip
L. plantarum is among the most studied strains for actually surviving the GI tract. Strongest research backing for gut barrier function and reducing intestinal inflammation.
de Vries et al., International Dairy Journal (2006) · Le & Yang, Toxicology Reports (2018)
Consumer study
87% reported less bloating by month 3
Third-party study, 40 women, three months. Surface comfort shifted in month 1; deeper changes compounded by month 3. Not a placebo curve.
- 86% reduced reflux
- 89% more regular digestion
- 95% reduced vaginal odor
n=40 · 3 months · self-reported
4B
CFU · 2 clinically-relevant strains
240mg
Standardized ginger (5% gingerols)
500mg
Prebiotic blend (psyllium + acacia)
100%
Vegan capsules · no fillers · no flow agents
What to expect
Bloating eases in week 1. The whole loop reshapes by month 3.
A root-level shift, not a shortcut.
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Week 1
Surface gut comfort shifts
Less bloating, as ginger calms the enteric nervous system fastest.
-
Weeks 2–3
Digestive rhythm stabilizes
Reflux, regularity, and energy ease as inflammation in the gut wall settles.
-
Month 1
The strains are establishing
Vaginal terrain begins to shift. The mood-gut connection becomes noticeable.
-
Month 3+
The loop in different shape
The cycle, the gut, and the mood are moving with you instead of against you.
The microbiome doesn't get sorted once. It gets supported, daily. Presence is what compounds.
“I was so constipated on a GLP-1. This helped keep things flowing and takes my bloat away.”
Less bloating. Better cycles. Steadier days.
Real women on what shifted when they started supporting both sides of the gut-hormone loop daily.
Pre+Probiotic For Women
Gut Health, Microbiome Support
Both sides of the gut-hormone loop. 4 billion CFU, 240mg standardized ginger, 500mg prebiotic blend. Daily work, at the root.*
Go deeper
Want both ends of the loop? Meet The Microbiome Protocol.
Pre+Probiotic supports the gut-hormone loop. There's a layer underneath: the daily nutrients your body uses to act on what the gut produces.
That layer is Hormone Balance, our daily nutrient foundation.
Together, they're The Microbiome Protocol. The gut produces. The foundation lets your body use it.
- Pre+Probiotic supports the gut-hormone loop (both sides)
- Hormone Balance is the daily foundation that lets your body use what the gut makes
- Together, two compounding timelines, one continuous biology
View Supplement Facts:
Why The Microbiome Protocol?
-
Two compounding timelines, in parallel
-
90% of serotonin is gut-made. Active-form B vitamins convert it.
-
40% of women need methylated B vitamins (MTHFR variants).
Third-party tested
Vegan
GMP certified
No fillers
Dairy free
Gluten free
Soy free
Women-owned
Your daily
2 capsules. Daily. With food.
The microbiome responds to daily presence, not occasional use.
2 capsules. Mornings. With food.
Daily presence is the work.
Give it 90 days.
Surface comfort first, deeper shifts compound. A root-level shift, not a shortcut.
Questions
The biology you came in with, answered.
How long until I notice a difference?
Surface comfort (bloating, reflux) often shifts in the first week as the enteric nervous system responds to ginger. Microbial-side changes (regularity, vaginal terrain, mood-gut) compound across months 1 to 3. The loop reaches steady state around month 6.
Do I need to refrigerate it?
No. L. acidophilus and L. plantarum are shelf-stable at room temperature, and our manufacturing protects viability through the bottle's shelf life. Refrigeration is optional.
Can I take this with antibiotics?
Finish your antibiotic course first, then start. Antibiotics disrupt the microbiome for 6 to 12 months. Daily Pre+Probiotic during that window supports the rebuild on both sides of the loop.
I have a sensitive gut. Will this cause bloating at first?
Some women notice their digestion adjusting in the first few days as the strains establish. It usually settles within a week. We chose acacia gum specifically because it's well-tolerated even by sensitive guts (low-FODMAP).
Can I take this if I'm pregnant or breastfeeding?
Always check with your healthcare provider before starting any new supplement during pregnancy or while breastfeeding.
What if I'm already taking another probiotic?
You don't need to stack. Pre+Probiotic is a complete formula on its own (prebiotics, strains, and ginger working together). Replace your current probiotic with this one.
How is this different from a standard probiotic?
Two things. First, the prebiotic blend prepares the terrain so the strains can actually establish. Second, the standardized ginger addresses the enteric nervous system, the gut's own nerve network. That's the side most probiotics ignore.
What's the difference between this and The Microbiome Protocol?
Pre+Probiotic supports the gut-hormone loop. The Microbiome Protocol adds Hormone Balance, the daily foundation your body uses to act on what the gut produces (active-form B vitamins, magnesium, zinc, bioactives). Pre+Probiotic alone if you're focused on gut comfort and mood-gut. The Microbiome Protocol if you want both ends daily.
Your gut and your mood are the same conversation.
Pre+Probiotic for Women. Both sides of the gut-hormone loop. Daily.