FAQ

To get the most of all the supportive goodness in Semaine, you should start taking Semaine 1–2 days before you start bleeding. This helps your body prepare and support the increased inflammatory response that will occur during menstruation before it’s reached its peak discomfort point.

That’s okay; we know periods are hard to predict. Start as soon as you can and keep taking all 7 days of pills even if your period stops before then. This supports your body's healthy response to inflammation even as your period is winding down.

We recommend starting Semaine when you come off of the hormones. For example, if you are using pills, start your 7-day course of Semaine when you switch over to the placebo pills for 7 days. Or if you use something like the NuvaRing, start Semaine when you take the ring out. Take 2 pills in the morning and 2 pills in the evening. You don’t have to take the pills with food, but doing so helps with absorption.

If you occasionally bleed or have PMS symptoms with your IUD, start taking Semaine as soon as either starts. Take 2 pills in the morning and 2 in the evening for 7 days.

If you use an app, or track your cycle, we would recommend starting Semaine 1 or 2 days before your period begins. This helps your body to prepare for the natural stress of bleeding (yup, your body naturally has more inflammation as your period starts). If you don’t know when your period is likely to start, begin Semaine on the first day of your period.

Take 2 pills in the morning and 2 pills in the evening for 7 days. If your period is shorter or longer than 7 days, that’s okay. Taking the pills for 1 week ensures you get a steady does of goodness to support a healthy inflammatory response right when your body could use the boost.

We recommend taking Semaine with food to aid absorption, but we’ve formulated our pills to be super bioavailable. That means we’ve taken an extra step to make sure that it causes as little upset to your stomach as possible, so you can take Semaine without food.

Don’t stress, just double up at the next meal and take your 4 pills at once. Semaine works best if you spread it out during the day, but if you take a double dose one day, it still helps support a healthy inflammatory response when you need it.

We know life gets busy, so don’t worry! Just pick up where you left off and continue taking 4 pills each day for 7 days (even if your period ends before then).

One of our cofounders (Lar) has an extremely sensitive stomach, and Semaine PMS was developed with this sensitivity in mind, which is why we make sure our ingredients are easily digestible and bioavailable by wrapping them in phytosomes. A phytosome is a fat (sunflower lecithin) wrapped around each molecule of our ingredients to make sure it is easier on your stomach, and you absorb more of it. Lar was our very first beta tester for Semaine and never had problems with taking the pills with or without food.

If you are currently pregnant, trying to get pregnant, or breastfeeding, please check with your doctor before you add any new supplement to your regime, including Semaine.


As your body enters menstruation, one of its tasks is to shed and expel your uterine lining. It does this by creating molecules called prostaglandins that trigger inflammation and cramping. This process is stressful, and if your body is stressed going into your period, that can mean more inflammation and worse cramps. People with more prostaglandins have worse cramps, and Semaine supports your body and helps support your natural response to inflammation.

We’ve all heard that bloating is caused by water retention during our periods, but another contributing factor is inflammation. When our pelvis feels more inflamed, that adds to the red-hot, stretched feeling of being bloated. By helping support your body's natural inflammatory responses in multiple ways, each of the 9 plant-based ingredients in Semaine work together to support a health inflammatory response, which helps to decrease your bloating.

Inflammation is one way your body tries to signal and coordinate your immune system to repair or attack invaders. Pregnancy involves a bunch of cells that have half your DNA (from the egg) and that have half foreign DNA (from the sperm). Because your body likes to attack cells that have DNA isn't yours, it dials back the immune system and associated inflammation around ovulation in case pregnancy should occur. If pregnancy doesn’t happen, then your body switches back into bad-ass fighter mode as it cycles toward your period. We love that our body is looking out for us, but the response can be a little too strong, which can result in a lot of excess inflammation and is one reason you can end up with lots of cramps or bloating on your period. Basically, if you have lots of cramps, your body is just really good at fighting for you. Maybe just a little too good. For more details on inflammation, check out our period primer, or inflammation 101.

There are a lot of different reasons that your body might have a lot of inflammation and make your periods worse—some that are in your control and some that aren’t. For example, people with diseases like endometriosis or adenomyosis have worse inflammation linked to their disease. As cofounders with endometriosis, we know how unpleasant that is. Some inflammation can also be caused by lifestyle: stress, diet, too much exercise, or too little.

Nope! Semaine specifically helps to support your body and helps to promote a healthy inflammatory response when you need it the most. We all have inflammation during our cycles, but our hormone levels are very different for each of us.

Your body experiences a really large spike in inflammation right before and during your period. Semaine helps support you during that spike while fitting into your life. We know how inconvenient it is to take a pill every day, and Semaine provides you with the biggest dose of anti-inflammatories when you need it the most. Our bodies do not have the same level of inflammation throughout our cycle, so we don’t need to take the same dose every day.

Semaine’s plant-powered approach helps reduce cramps an and bloating for most users during their first month, but many people even better results taking the supplements from cycle to cycle. In many clinical studies using the ingredients in Semaine to evaluate how they can improve bloating, cramps, and PMS symptoms, participants experienced a gradual improvement over several months. Ninety percent of our beta testers experienced a reduction in bloating and cramps during their first month on Semaine PMS, but other improvements may take time.

There is a loop between inflammation and estrogen where they feed on one another to boost both inflammation and estrogen levels. High estrogen leads to high inflammation, which in turn leads to higher estrogen, which leads to higher inflammation. This has been extensively studied; here is a good article if you want to read more. Supporting your body's healthy inflammatory response could help it deal with this better in the long run.

Eat more vegetables and fiber. As you enter your period, your body is trying to get rid of estrogen, so your liver is pulling it out of your blood and then sending it to your intestines through your bile ducts. Estrogen floating around in your intestines can get reabsorbed, but fiber absorbs the estrogen a bit like a sponge and carries it out of your body.


Yes it is! We wanted to make sure that Semaine fit into your lifestyle whether you are vegan, vegetarian, or just plant-curious. Everything from the capsules to the ingredients was carefully sourced to ensure it fits into a vegan lifestyle.

Supporting your body so it can deal with inflammation on your period is a complex issue. Rather than just trying to take a hammer and provide megadoses of a single supplement, we believe it is important to support multiple aspects of your body's natural inflammatory response. By addressing multiple parts instead of just one, your body can be better supported and heal faster. The different ingredients in Semaine have been clinically shown to address different parts of the immune system and support your body's response to inflammation in different ways, and by working in tandem to do more than just one ingredient could. Not all plant-based ingredients work along the same pathways. For instance, curcumin helps support mood and a response to inflammation, while green tea catechins help with oxidative stress, and quercetin helps ensure support your body balancing histamine levels. Having multiple ingredients to support your health in different ways is a holistic approach to support a healthy response to inflammation.

Supplements are regulated by the FDA but not approved by it. Our pills are manufactured in an FDA-regulated facility, and we rigorously test not only the initial supplements we receive from suppliers, but the final pills as well.

We’ve devoted a lot of energy to sorting through the science of how your body absorbs supplements. Many plant extracts aren’t very water soluble and have a hard time getting absorbed as they travel through your intestine. So we’ve tracked down the highest-quality ingredients that are encapsulated inside sunflower lecithin (a kind of fat). These are from our European suppliers, and encapsulating the supplement in a liposomal-like structure helps you to absorb up to 30 times more of each supplement. These are a lot more expensive than the materials used in most supplements you see on the shelf at your grocery store, but we formulated Semaine to be absorbed in your body so you can get the most from each little green pill.

Sourcing the best ingredients for Semaine was our most important mission when we started our formulation. We wanted the highest-quality supplements that can be absorbed by your body, so we tracked down the best versions from around the world. Six of our ingredients are sourced from Italy, two from the U.S., and one from India. Details on all our suppliers can be found on our ingredients page.


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Just log in to your account and click pause or change the next delivery date. If you are having any issues with this, please contact support@semainehealth.com.

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Always for subscriptions. For single purchases, there is a small fee to cover shipping costs.

Absolutely! International friends, we can't send subscriptions out yet, but you can order multiple bottles to reduce shipping costs. You may owe duties on products that enter your country, so please be aware of this.

Shipping can be a bit variable with evrerything going on, but generally shipping takes 3-6 days.

We’ll take care of that for you. We want you to have your best periods, and part of that is a stress-free lifestyle. Just message us in our chatbot or shoot us an email

You’ll receive an email when your order is shipped, and the same goes with your subsequent orders. You’ll get email notifications throughout the length of your subscription.

If there is an issue with your order, please get in touch at support@semainehealth.com and we’ll make it right.