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Our research

Clinical Studies

Semaine funds its own studies, has them run independently, and builds on published research. When the evidence is strong, we say so with specificity. When it's exploratory, we say that too. Here is what our studies found, and how they were run.

Want the full detail? Download our product white papers.

Written and reviewed by Matt Crane, PhD, Co-Founder & Chief Science Officer · Last reviewed July 2026

Behind the science

After earning his PhD in bioengineering from Georgia Tech, Matt watched his wife Lauren's endometriosis worsen. As they met with more and more doctors, it became clear how little was known about the condition, so he decided to take matters into his own hands.

He went on to the University of Washington School of Medicine, where he studied the biology of aging and the role of environment and inflammation in chronic conditions. He began investigating how different compounds worked with Lauren and her sister Catherine, eventually leaving his faculty position to co-found Semaine, where he leads the formulation team.

Meet Matt, our Chief Science Officer

Our standards

  • Plant-based

    We're bridging the gap between natural wellness and pharmaceuticals.

  • Unbiased data

    We continuously research the latest published clinical data from the top medical and science journals.

  • Third-party testing

    Our studies and formulations go through rigorous third-party testing to keep everything honest and unbiased.

Our promise

We've been in your shoes. We know what it's like to have your health concerns not taken seriously, and how deeply that can affect you. We promise your challenges will be seen, heard, and addressed, with formulas built on real research and tested honestly.

How to read our studies

Semaine funds its studies and has them run independently by Citrus Labs, a third-party research firm. Here is what the terms on this page mean.

Open-label means participants knew they were taking the product; there was no placebo group. Observational means we tracked what happened over time rather than comparing against a control. A consumer perception study records what participants reported about how they felt. A cross-over study has each participant serve as her own comparison. A validated scale, like the Menopause Rating Scale, is a standardized questionnaire used in research.

Because these studies are open-label, a figure like "90% reported improvement" reflects what participants experienced and reported. It is not the same as a placebo-adjusted effect from a randomized controlled trial. Where we cite a randomized controlled trial (RCT), we say so and name the publication.

The studies

StudyDesignParticipantsRegistrationKey finding
Menopause Hormone Support Open-label observational study 42 women NCT05617287 93% reported improvement in hair quality, brain fog & exhaustion (p<0.001)
The Daily Hormone Balance Open-label observational study 45 women NCT05328609 Significant improvement in fasting insulin (p<0.05) & cholesterol (p<0.001)
PMS Relief Capsule Open-label observational cross-over study 48 women NCT05019924 Significant reduction (p<0.01) in every symptom surveyed
Pre+Probiotic for Women Consumer perception study 40 women Not registered 95% reported improvement in vaginal odor; gains compounded over 3 months
Urinary Tract Cleanse & Protect Consumer perception study 48 women Not registered 89% reported improvement in urinary environment; RCT-supported ingredient

Menopause Hormone Support

Steadying the systems during the most volatile years

This is the Semaine-run study, with published research behind this formula below.

A three-month study in women in active perimenopause and early menopause, tracked on the validated Menopause Rating Scale at baseline and the end of each month.

  • 42 women participated
  • 40–57 age range
  • 1 capsule daily
  • 3 months
  • Open-label observational study
  • Registered: NCT05617287
  • 93%reported improvement in hair quality
  • 93%reported improvement in brain fog
  • 90%reported improvement in hot flashes
  • 90%reported improvement in night sweats
  • 90%reported improvement in irritability
  • 88%reported improvement in anxiety

By the three-month endpoint, 93% also reported improvement in sexual satisfaction and in physical and mental exhaustion. Participant frequency logs showed a 69% reduction in the number of hot flashes per day and an 80% reduction in nighttime sweats. Severity of every reported symptom was significantly decreased (p<0.001).

See the full month-by-month data (14 symptoms)
SymptomMonth 1Month 2Month 3
Hot flashes / sweating76%79%90%
Night sweats86%88%90%
Heart discomfort55%67%71%
Sleep problems74%88%86%
Depressive mood71%79%81%
Irritability83%88%90%
Anxiety76%79%88%
Physical & mental exhaustion76%88%93%
Brain fog86%86%93%
Sexual satisfaction76%81%93%
Bladder comfort64%69%71%
Hair quality74%74%93%
Vaginal comfort76%83%86%
Joint & muscular comfort67%71%76%

Independently conducted by Citrus Labs and funded by Semaine. In a three-month observational study of 42 women experiencing multiple hot flashes per day, percentages reflect the share of participants reporting improvement on the Menopause Rating Scale.

Read the product white paper (PDF)

Published research behind this formula (8)

Peer-reviewed research on the ingredients and mechanisms in this formula. This is the published literature the formula is built on, separate from Semaine's own study above.

Soy isoflavones

Red clover

Olive polyphenols

Bergamot

My energy and emotions are back to where they were before perimenopause struck. I'm also sleeping better and waking up feeling more refreshed.
Pam · California

Individual experience. Results vary.

Explore Menopause Support

The Daily Hormone Balance

Daily support you can see in the biology

This is the Semaine-run study, with published research behind this formula below.

A two-month study pairing self-reported symptom change with measured blood biomarkers, collected through at-home dried-blood-spot testing.

  • 45 women participated
  • 2 capsules daily
  • 2 months
  • Open-label observational study
  • Registered: NCT05328609
  • 86%reported improved mood
  • 78%reported more energy
  • 81%reported less anxiety

Participants showed a significant improvement in fasting insulin (p<0.05) and in total cholesterol (p<0.001), both measured biomarkers. Alongside the biomarker shifts, participants reported significant improvement in mood swings, time to fall asleep, energy levels, and anxiety. Pairing measured metabolic change with reported symptom change is what makes this study stronger than a perception study alone.

Independently conducted by Citrus Labs and funded by Semaine. In a two-month observational study (n=45), biomarker results are measured; symptom results are self-reported and attributed to the study and its methodology.

Read the product white paper (PDF)

Published research behind this formula (9)

Peer-reviewed research on the ingredients and mechanisms in this formula. This is the published literature the formula is built on, separate from Semaine's own study above.

Grape seed

Berberine

Zinc

Sucrosomial magnesium

Magnesium

Passionflower

I have fewer breakouts and fewer blood sugar crashes during my day.
Brittney · California

Individual experience. Results vary.

Explore Hormone Balance

PMS Relief Capsule

A cross-over study, each woman her own control

This is the Semaine-run study, with published research behind this formula below.

Participants experienced one baseline cycle without the capsule and one cycle with it, taking it only around and during their period, the way it is actually used.

  • 48 women participated
  • 18–40 age range
  • 2 capsules, 3x per day during your period
  • Cross-over (baseline cycle vs. intervention cycle)
  • Open-label observational cross-over study
  • Registered: NCT05019924
  • 88%reported less overall discomfort
  • 73%reported fewer mood swings
  • 75%reported milder period poops

Every symptom surveyed showed a significant reduction (p<0.01) between the baseline cycle and the intervention cycle, including cramping, digestive upset, mood swings, and bloating. The cross-over design, where each woman serves as her own control, is a methodological strength.

Independently conducted by Citrus Labs and funded by Semaine. In a cross-over study (n=48), every symptom surveyed showed significant reduction (p<0.01) between the baseline cycle and the intervention cycle.

Read the product white paper (PDF)

Published research behind this formula (9)

Peer-reviewed research on the ingredients and mechanisms in this formula. This is the published literature the formula is built on, separate from Semaine's own study above.

Curcumin and boswellia

Vitamin D

Magnesium

Lemon balm

Boswellia

I've tried everything and this is the only thing that has tackled my pain and helped me feel normal.
Jojo · Washington

Individual experience. Results vary.

Explore Period Support

Pre+Probiotic for Women

Gut comfort that compounds over three months

This is the Semaine-run study, with published research behind this formula below.

A three-month consumer perception study following self-reported change across gut, digestive, and related symptoms at monthly time points.

  • 40 women participated
  • 18–65 age range
  • Daily
  • 3 months
  • Consumer perception study
  • 95%reported improvement in vaginal odor
  • 89%reported improvement in constipation
  • 87%reported improvement in bloating
  • 86%reported improvement in acid reflux
  • 85%reported improvement in gut irritation
  • 83%reported improvement in loose stool

The trajectory is part of the story: faster-acting symptoms like reflux and bloating showed strong results by month one and held, while slower-acting shifts like constipation and the vaginal microbiome compounded across months one to three.

See the month-by-month data
SymptomMonth 1Month 3
Acid reflux81%86%
Bloating79%87%
Constipation67%89%
Vaginal odor74%95%
Gut irritation77%85%
Loose stool83%Not reported

Independently conducted by Citrus Labs and funded by Semaine. In a three-month consumer perception study (n=40), results reflect what women reported over time, attributed to the study and its methodology.

Read the product white paper (PDF)

Published research behind this formula (8)

Peer-reviewed research on the ingredients and mechanisms in this formula. This is the published literature the formula is built on, separate from Semaine's own study above.

Lactobacillus acidophilus

Lactobacillus plantarum

Probiotic blend

Ginger

Prebiotic fibre

Explore Pre+Probiotic

Urinary Tract Cleanse & Protect

Two kinds of evidence for urinary tract health

This is the Semaine-run study, with published research behind this formula below.

Anthocran® Phytosome®, a standardized cranberry extract built for absorption, is supported by published peer-reviewed research and by Semaine's own five-month consumer perception study.

  • 48 women participated
  • 40+ age range
  • Daily
  • 5 months
  • Consumer perception study
  • 89%reported improvement in urinary environment
  • 89%reported improvement in bladder comfort
  • 86%reported improvement in urinary tract comfort
  • 81%reported improvement in nighttime urination

In a 2024 RCT published in Nutrients, daily supplementation with 120mg of cranberry phytosome significantly modulated the frequency of urinary tract episodes compared to placebo in postmenopausal women with type 2 diabetes taking SGLT-2 inhibitors, a population at substantially elevated urinary tract risk. Cranberry phytosome may help support urinary tract health and comfort.

See the full five-month data
SymptomM1M2M3M4M5
Bladder comfort63.9%83.3%83.3%88.9%80.6%
Urinary tract comfort68.6%74.3%77.1%82.9%85.7%
Nighttime urination46.3%58.5%78.0%80.5%78.0%
Urinary environment57.9%68.4%68.4%89.5%84.2%
Pelvic comfort61.1%66.7%72.2%77.8%75.0%
Vaginal defenses65.7%82.9%77.1%85.7%77.1%

Independently conducted by Citrus Labs and funded by Semaine. In a five-month consumer perception study (n=48, women aged 40+), results reflect what women reported over time, attributed to the study and its methodology.

Read the product white paper (PDF)

Published research behind this formula (6)

Peer-reviewed research on the ingredients and mechanisms in this formula. This is the published literature the formula is built on, separate from Semaine's own study above.

Cranberry

As a mom of two littles, I do not have time to waste. This has been a great addition to my daily routine, helping me feel great.
Nancy · Washington

Individual experience. Results vary.

Explore Bladder Health

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Semaine's studies are observational and consumer perception studies, not placebo-controlled randomized controlled trials (RCTs); results reflect what participants reported and are attributed to each study and its methodology.

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