Matt Crane, PhD
Co-Founder and Chief Science Officer
Bioengineering / quantitative and cellular aging biology
Current affiliation
Semaine Health (Co-Founder, Chief Science Officer)
Education and training
PhD, Bioengineering, Georgia Institute of Technology; postdoctoral research fellow / acting instructor, University of Edinburgh; senior fellow (postdoctoral trainee), Department of Pathology, University of Washington School of Medicine
Selected publications
- Chung K, Crane MM, Lu H. Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans. Nat Methods. 2008;5(7):637-643.
- Stirman JN, Crane MM, Husson SJ, Wabnig S, Schultheis C, Gottschalk A, Lu H. Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans. Nat Methods. 2011;8(2):153-158.
- Crane MM, Clark IBN, Bakker E, Smith S, Swain PS. A microfluidic system for studying ageing and dynamic single-cell responses in budding yeast. PLoS One. 2014;9(6):e100042.
- Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, et al. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013;3(5):1465-1475.
- Crane MM, Chung K, Stirman J, Lu H. Microfluidics-enabled phenotyping, imaging, and screening of multicellular organisms. Lab Chip. 2010;10(12):1509-1517.
- Crane MM, Stirman JN, Ou CY, Kurshan PT, Rehg JM, Shen K, Lu H. Autonomous screening of C. elegans identifies genes implicated in synaptogenesis. Nat Methods. 2012;9(10):977-980.
- Crane MM, Chung K, Lu H. Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system. Lab Chip. 2009;9(1):38-40.
- Rempel IL, Crane MM, Thaller DJ, Mishra A, Jansen DPM, Janssens G, et al. Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics. eLife. 2019;8:e48186.
- Chen KL, Crane MM, Kaeberlein M. Microfluidic technologies for yeast replicative lifespan studies. Mech Ageing Dev. 2017;161(Pt B):262-269.
- Stirman JN, Crane MM, Husson SJ, Gottschalk A, Lu H. A multispectral optical illumination system with precise spatiotemporal control for the manipulation of optogenetic reagents. Nat Protoc. 2012;7(2):207-220.
- Cerulus B, Jariani A, Perez-Samper G, Vermeersch L, Pietsch JMJ, Crane MM, et al. Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources. eLife. 2018;7:e39234.
- Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, et al. Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. PLoS Genet. 2017;13(3):e1006695.
- Granados AA, Crane MM, Montano-Gutierrez LF, Tanaka RJ, Voliotis M, et al. Distributing tasks via multiple input pathways increases cellular survival in stress. eLife. 2017;6:e21415.
- Mouton SN, Thaller DJ, Crane MM, Rempel IL, Terpstra OT, Steen A, et al. A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast. eLife. 2020;9:e54707.
- San-Miguel A, Kurshan PT, Crane MM, Zhao Y, McGrath PT, Shen K, Lu H. Deep phenotyping unveils hidden traits and genetic relations in subtle mutants. Nat Commun. 2016;7:12990.
- Bakker E, Swain PS, Crane MM. Morphologically constrained and data informed cell segmentation of budding yeast. Bioinformatics. 2018;34(1):88-96.
- Crane MM, Sands B, Battaglia C, Johnson B, Yun S, Kaeberlein M, et al. In vivo measurements reveal a single 5' intron is sufficient to increase protein expression level in Caenorhabditis elegans. Sci Rep. 2019;9(1):9192.
- Kurshan PT, Phan AQ, Wang GJ, Crane MM, Lu H, Shen K. Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology. J Neurosci. 2014;34(38):12678-12689.
- Chen KL, Ven TN, Crane MM, Brunner MLC, Pun AK, Helget KL, et al. Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae. Geroscience. 2020;42(2):749-764.
