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4.5 · 3,400+ reviews across Semaine
Recommended by 300+ clinicians

Some mornings you wake up and don’t recognize the woman in the mirror.

  • 93% said brain fog improved*
  • 93% said exhaustion improved*
  • 88% said anxiety improved*

*Self-reported after 3 months of daily use. 42-woman trial, NCT05617287.

Semaine Peri/Menopause Essentials
As seen in
First, this

You went to bed fine. You woke up someone else.

You’re awake at 3:17am for no reason your brain can name. You snap at someone you love over something that wouldn’t have registered last year. You’re hot, then cold, then hot again, in the middle of a meeting.

You google one symptom and get told it’s stress. You google another and get told it’s age. You mention it to your doctor and get told your labs are “normal.”

Nothing is wrong with you. Something is shifting underneath you.

It might be perimenopause years before anyone names it that. Estrogen starts fluctuating in your 40s, sometimes earlier, and your body adapts long before you’ve put a word to what’s happening.

Estrogen levels across the transition: stable cycles in the 30s, increasing fluctuation through the 40s, dramatic swings in late peri, lower stable levels post-menopause
Estrogen doesn’t disappear. It fluctuates, sometimes for years before menopause is “over.”

None of it is in your head. None of it is a flaw. It’s a transition with a name, and a reason every symptom is hitting at once.

Why all of this is happening at once

Estrogen, the project manager of six systems.

  • Brain chemistry
    mood, brain fog, irritability
  • Metabolism
    energy, weight, cravings
  • Sleep
    broken sleep, 3am wakes, night sweats
  • Cardiovascular
    hot flashes, palpitations
  • Stress response
    anxiety, on-edge, overwhelm
  • Inflammation
    joint discomfort, achiness

You don’t have a sleep problem. You don’t have a mood problem. You have a project manager in flux, and every system she runs is asking for support.

The Mediterranean discovery

Three Mediterranean compounds. For the six systems estrogen runs.

Researchers studying menopause across populations kept finding the same thing: women in Mediterranean countries had measurably milder transitions. Fewer hot flashes. Better sleep. More stable mood. The reason wasn’t culture. It was three specific plant compounds women in those regions consumed daily, at doses food alone delivers.

Those three compounds, isolated and standardised at clinical doses: hydroxytyrosol from olive, red clover isoflavones, and bergamot phytosome. The Mediterranean diet, distilled.

Non-hormonal. Two of three carry EU-approved health claims.

Three Mediterranean compounds mapped to the systems estrogen regulates: focus, hair, hot flashes, joints, calm, energy
This is for you if…

Made for the woman whose body is shifting underneath her.

Best match A great fit
Not the
right fit
Not the right fit
Something’s shifted, and you feel it
Sleep, mood, hot flashes, brain fog
You want to support it, not push through
You want clinical evidence
One formula, not five
Soy or black cohosh hasn’t moved the needle
You want symptoms gone overnight
×
You’re looking for hormone replacement therapy
×
Peri/Menopause Essentials bottle with capsule
If you’ve tried supplements and felt nothing, here’s why

Four isoflavones, not two.

Most menopause supplements lean on soy, which contains two isoflavones: daidzein and genistein. It’s why so many women try them for six weeks, feel nothing, and conclude “supplements don’t work for menopause.”

Red clover contains four: formononetin, biochanin A, daidzein, and genistein. Each binds estrogen receptors differently, with preferential affinity for ERβ, the receptors that govern bone, brain, and vascular tissue during menopause.

Twice the receptor coverage. The difference between “felt nothing” and a 90% hot-flash response in trial.

Red clover isoflavones

Four isoflavone types: formononetin, biochanin A, daidzein, genistein. Broader receptor coverage with ERβ preference.

Red clover isoflavones — four types, broader receptor coverage

The EU-approved hot-flush claim is on red clover isoflavones, not on soy.

Three compounds, every day

Three compounds. Three jobs.

Hydroxytyrosol

20mg · from extra virgin olive oil · EU-approved
  • Inflammation
  • Cardiovascular
  • Brain chemistry

The compound behind olive oil’s cardiovascular reputation. Anti-inflammatory. Neuroprotective. The reason Mediterranean women’s hearts, joints, and brains age the way they do: slowly, and well.

Red Clover Isoflavones

50mg · 4 isoflavone types · EU-approved for hot flushes
  • Cardiovascular
  • Brain chemistry
  • Bone

Twice the isoflavone coverage of soy, with preferential affinity for ERβ receptors that govern bone, brain, and vascular tissue: the systems most affected by your transition.

Bergamot Phytosome

100mg · from the Calabrian coast · phytosome delivery
  • Metabolism
  • Lipids
  • Energy

For the metabolic and lipid shifts that show up during menopause: the weight that won’t budge, the cholesterol climbing for no reason, the energy that disappeared. Standard bergamot barely makes it past your gut. The phytosome form gets where it needs to go.

Most products target one symptom. This formula supports every system estrogen runs.

Most menopause
supplements
Best choice Peri/Meno
Essentials
Peri/Menopause Essentials
Four isoflavone types (not just two)
×
EU-approved hot-flush health claim
×
Phytosome delivery (not standard extract)
×
Third-party clinical trial on the actual formulation
×
Supports all six systems estrogen runs
×
Studied. Measured. Published.

The formula, in trial.

Third-party trial (Citrus Labs), registered at ClinicalTrials.gov as NCT05617287. Measured on this exact formulation, after three months of daily use.

90%
reported fewer hot flashes
Cardiovascular
93%
reported less brain fog
Brain chemistry
86%
reported better sleep
Sleep architecture
90%
reported less irritability
Stress response

Self-reported, women 40–57, 14 measures across 3 months. Two ingredients carry EU-approved health claims.

Tilted Peri/Menopause Essentials bottle with capsules
Bottle with Mediterranean leaves
What the trial measured at each month

The shift compounds, month over month.

The trial tracked 14 measures. The curve is real.

  1. Month 1

    Early shifts in mood, sleep, and clarity.

    86% less brain fog. 83% less irritability. 74% better sleep.

  2. Month 2

    The lift broadens.

    Sleep climbs to 88%. Exhaustion and irritability both join it at 88%.

  3. Month 3

    Hair catches up.

    90% fewer hot flashes. 93% less brain fog. 93% thicker hair. Where the trial stopped measuring, not where the body stops responding.

  4. Year 1+

    The longer arc.

    Mediterranean women built milder transitions over decades, not months. The compounds keep working as long as you do.

It compounds. Day after day, year after year.

“About three weeks after starting, my night sweats were gone and I haven't had any since. I'm sleeping through the night now.”
Brittany C. · Verified Buyer · Age 35–44
“I'm 46. I was having hot flashes all the time, day and night. I started Peri/Menopause and the hot flashes have 98% stopped.”
Jessica K. · Verified Buyer · Age 45–54
“I'm unable to take hormones so I'm so thankful to find some relief. This has really helped stabilize my moods and reduce irritability.”
Ashley H. · Verified Buyer · Age 35–44

Real women. Real transitions.

First-hand stories from women using Peri/Menopause Essentials — what changed, and what they'd tell a friend.

4.55 · (576)

Peri/Menopause Essentials

Three Mediterranean compounds. Clinically studied.

Hydroxytyrosol from olive, four-isoflavone red clover extract, and bergamot phytosome. Two ingredients carry EU-approved health claims. Non-hormonal.*

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Peri/Meno Essentials

Supplement Facts

Peri/Meno Essentials Supplement Facts panel
Hormone Protocol — Peri/Menopause Essentials with Hormone Balance
The Hormone Protocol

Two halves of menopause. One protocol.

Menopause is two things at once: the hormones changing, and the foundation your body still needs every day. The Hormone Protocol addresses both.

  • Peri/Menopause Essentials: the changing hormones (phytoestrogens with ERβ preference)
  • Hormone Balance: the foundation underneath (brain chemistry, sleep, mood, metabolic regulation)
  • Together: two halves, one menopausal experience

View Supplement Facts:

Peri/Meno Essentials

Supplement Facts

Peri/Meno Essentials Supplement Facts panel

Hormone Balance

Supplement Facts

Hormone Balance Supplement Facts panel

Continue with Peri/Menopause Essentials only

Why add Hormone Balance to the protocol?

  • Active-form B vitamins for the serotonin and dopamine pathways

  • Sucrosomial magnesium for nervous-system steadiness and sleep

  • Berberine phytosome for metabolic and blood sugar support

  • Signal layer plus downstream layer. Two compounding timelines, one transition.

Non-hormonal
Gluten free
Dairy free
Soy free
No artificial colours
Third-party tested
Non-GMO
How to take it

Daily, through the transition.

1

Two capsules with food, every morning

Phytoestrogen activity is steadying, not relief. The benefits compound the longer you stay.

2

Across the transition, not just for symptoms

Early peri, mid-meno, or post. The support builds underneath the transition. No timing tricks. No cycle tracking.

Peri/Menopause Essentials bottle
Common Questions

FAQs

Is this hormone replacement therapy?
No. The active compounds are phytoestrogens: plant compounds with affinity for estrogen receptors, not hormones. They support the body’s response to the transition without introducing pharmaceutical hormones.
Can I take this with HRT?
Talk to your prescribing clinician. This is non-hormonal, not positioned as an alternative or a complement to HRT. Your physician knows your context and can advise.
How is this different from soy isoflavones?
Soy contains two isoflavone types. Red clover contains four, with preferential affinity for ERβ receptors, the ones most relevant to menopausal symptoms. The red clover form carries the EU-approved hot-flush claim; soy doesn’t.
When will I feel a difference?
Brain fog and irritability shift earliest. 86% and 83% improved after one month. Sleep climbs to 88% by month two. By month three, the trial recorded 90% on hot flashes and 93% on hair. Most women describe the bigger shift around the three-month mark, and the support continues compounding from there.
I’m in early perimenopause. Is it too soon?
No. Early peri is often when the variability is hardest to read, since symptoms come and go. The support is built around the transition itself, not any one symptom, so it works at any phase of peri or post. And the earlier the steadying begins, the more the formula has to work with.
I have a personal or family history of hormone-sensitive cancer. Is this safe?
Phytoestrogens behave differently from pharmaceutical hormones, but talk to your oncologist or physician before starting any new supplement in this context. They know your history and can advise.
Why a 3-pack subscription?
Three months is the trial endpoint and when most women describe the bigger shift. The longer arc (phytoestrogen support, daily polyphenol protection, metabolic input) builds over years. The 3-pack subscribe is the lowest monthly price and keeps you in for the compounding window. Cancel anytime.

Three Mediterranean compounds. One quieter transition.

Non-hormonal. Clinically studied. The earlier you start, the more it steadies.

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