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4.5 ★ · 944 reviews Recommended by 859+ clinicians

You’re not doing sleep wrong. Your bladder can say “full” before it’s full.

Daily bladder care in one capsule. Meet Urinary Tract Cleanse & Protect.

Start My Plan →

Start with a 3-month plan or a single bottle

Sound familiar?

Every sleep tip, and still up at 3am.

This is for you if:

  • Bathroom trips wake you at night
  • Cutting back on water hasn’t helped
  • Getting back to sleep is the hard part

Not the right fit: new burning, pain or fever. See your doctor first.

The bathroom trip is quick. Getting back to sleep isn’t.

Give your bladder the care your bedtime routine leaves out.

  • ★★★★★

    “It has been wonderful...only up once at night sleeping so much better...Also can go so much longer when I go out for shopping without having to worry finding a bathroom....”

    Cheryl M., 65 and above · Verified buyer

  • ★★★★★

    “This supplement really seems to help. I wake up to pee in the night noticeably less often, which is great...”

    Crystal H., 45 to 54 · Verified buyer

4.5 ★ · 944 reviews

Start with the 3-month plan

free shipping

90-day money-back guarantee · single bottle also available

See My Options → First, why it happens ↓

Why “full” can arrive early

Your bladder isn’t a bucket. “Full” is a message.

Irritation can make your bladder signal “full” too soon.

  1. A wall full of nerves. They tell your brain when you’re full.

  2. An irritated lining can make nerves more sensitive.

  3. Sensitive nerves can signal early, like a smoke alarm tripped by shower steam.

  4. That “full” message can wake you, even when your bladder isn’t full.

“Full” isn’t only about how much you drank.

Bedtime changes leave out bladder care.

  • Sleep aids: Sleep aids help you fall asleep. Cleanse & Protect focuses on bladder care.

  • Drinking less: Cutting back hasn’t stopped the trips. Add daily bladder care.

  • Plain cranberry extract: Our patented cranberry phytosome is designed for absorption.

Why this cranberry

Cranberry delivery makes a difference.

Cleanse & Protect uses a patented cranberry phytosome designed for absorption.

Makes grabbing on harder

120 mg cranberry phytosome by Indena

Helps keep bacteria from sticking to the bladder wall.

Also in your daily capsule

240 mg hibiscus

Hibiscus flower extract in the same daily capsule.

83% reported less bladder irritation by month 3.*

*Self-reported consumer study, women 40+. Study details below.

★★★★★
“After the drugstore brand ... did nothing for me, I went looking for something better... I no longer have to worry about leaks or getting up in the middle of the night, which used to happen up to 3 times.”
Tinga M., 65 and above · Verified buyer

One small daily capsule. No bedtime timing.

What women reported

Most women reported fewer night trips by month 3.

Women who reported fewer nighttime bathroom trips, month by month.*

46%
Month 1
59%
Month 2
78%
Month 3
81%
Month 4

Your 3-month plan covers months 1 to 3.

Studied in women 40+.

*Five-month, self-reported study. Details.

Five-month consumer-perception study of women 40+ taking Cleanse & Protect daily, without a placebo. Percentages show women reporting improvement. Individual results vary.

Care for the bladder waking you.

Feature
Best choice Semaine
Cleanse + Protect
Melatonin
gummy
Made for daily bladder care
Included
No, compared with a plain melatonin gummy
Cranberry phytosome + hibiscus
Included
No, compared with a plain melatonin gummy
Melatonin-free
Included
No, compared with a plain melatonin gummy

Compared with a plain melatonin gummy.

Start My Plan →

Single bottle also available

Fewer night trips reported by month 3* · 4.5 ★ · 944 reviews

Advised by a Dedicated Medical Advisory Board

We partner with respected medical experts in gynecology, urology, and beyond who help shape our commitment to rigorous science and accessible, evidence-based education for women.

  • Dr. Michael Lewis
    OBGYN
  • Dr. Barbara Chubak
    Urologist
  • Dr. Jackie Crowell
    PT, DPT
Real names. Real comments.

Their words. Not ours.

  • 5,000,000+ capsules sold
  • 3,200+ verified reviews

A few of the comments women leave us on Facebook. There are thousands more.

Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer
Facebook comment from a Cleanse & Protect customer

90-day first-purchase guarantee

Try Cleanse & Protect for 90 days.

Not satisfied? Email us within 90 days of your first bottle’s shipping date. We’ll refund up to 2 bottles from your first purchase. Refund details.

Start My Plan →

Single bottle also available

Recommended by 859+ clinicians

Choose your plan.

78% reported fewer nighttime bathroom trips by month 3.*

  • 3 bottles

    90-day supply.

90-day first-purchase guarantee, up to 2 bottles · Free shipping on orders over $50 · Skip or cancel anytime · Single bottle also available

As easy as it gets.

One capsule with breakfast or a meal. No bedtime timing.

★★★★★
“I liked taking one smaller pill compared to the 3 others I was taking”
Marjorie R., 65 and above · Verified buyer

FAQ

Questions women ask

Cranberry is for UTIs. How does it help me sleep?

Cleanse & Protect is daily bladder care, with no melatonin or sedative.

Women taking Cleanse & Protect in our study reported fewer nighttime bathroom trips by month 3.* That means fewer interruptions to your night.

I already tried cranberry and it did nothing. How is this different?

Our patented cranberry phytosome is designed for absorption. Each capsule contains 120 mg cranberry phytosome by Indena and 240 mg hibiscus.

Do I have to stop drinking water at night?

No bedtime changes are needed to take Cleanse & Protect. Take one capsule with breakfast or a meal.

When will I notice a difference?

In our study, 46% reported fewer nighttime trips after month 1 and 81% by month 4.* Results vary.

Is this a UTI product?

Cleanse & Protect is daily urinary support, not an infection treatment. If you have signs of an active infection, like fever, back pain or blood in your urine, see a healthcare professional promptly.

How does the 3-month plan work?

3 bottles every 3 months, with free shipping. Renews automatically; skip or cancel anytime. A single bottle is also available without a plan.

Pregnant, breastfeeding, or taking medication?

Check with your healthcare professional before starting if you’re pregnant, breastfeeding, or taking medication.

What if it doesn’t work for me?

Email support@semainehealth.com within 90 days of your first bottle’s shipping date. We’ll refund up to 2 bottles from your first purchase. Shipping isn’t refundable; no return needed. Refund details.

Fewer night trips. More of your night.

One daily capsule. 90-day money-back guarantee.

Start My Plan →

Single bottle also available · free shipping on orders over $50

4.5 ★ · 944 reviews

90-day money-back guarantee

*Five-month consumer study, women 40+. See study details above.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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