Going Deeper: How Semaine’s Hormone Balance Gets to the Root of What’s Really Going On

Hair thinning. Mood swings. Fatigue. Sugar cravings. Insomnia. Acne. These are the symptoms people often associate with hormone “imbalance,” and they’re often chalked up to estrogen or progesterone fluctuations alone in women.

But in many cases, these symptoms are secondary effects of deeper physiological issues.

Let’s take a closer look:

• Hair loss or hirsutism (unwanted facial/body hair) Can be signs of elevated androgens, but those androgens are often driven by insulin resistance and inflammation.
• Mood instability We may often think about neurotransmitter imbalance, but mood can also influenced by micronutrient deficiencies (especially B vitamins) and blood sugar volatility.
• Low energy and poor sleep can stem from disrupted circadian regulation, adrenal stress, or lack of magnesium.
• Acne and skin issues Again, may be linked with both inflammation and insulin signaling.
• Cravings and metabolic issues Insulin resistance is a major underlying factor.

In other words, hormonal symptoms are often downstream from metabolic and nutritional dysfunctions.

Pharmaceuticals often focus on one target; Semaine’s approach is more holistic. The Hormone Balance formulation follows ADME principles:

• Absorption: Ingredients like berberine are notoriously hard to absorb. Semaine uses high-potency extracts and complementary cofactors (like B vitamins) to support uptake.
• Distribution: Botanicals and micronutrients are included in ratios that reflect their interactions in the body, not just their isolated effects.
• Metabolism: The formula supports healthy liver detox pathways (especially B6 and magnesium), which are essential for estrogen metabolism and hormone clearance.
• Excretion: By addressing inflammation and supporting gut function indirectly, Hormone Balance promotes healthy excretion of metabolized hormones.

Up to 88% of American adults are metabolically unhealthy, and insulin resistance is one of the most common root causes of “hormonal” symptoms. It’s associated with:

• Irregular periods
• PCOS and elevated androgens
• Acne
• Anxiety and depression
• Fatigue and weight gain
• Higher risk for dementia and heart disease

That’s why berberine is at the heart of this formula. In studies, berberine has been shown to improve insulin sensitivity and glycemic control, with efficacy comparable to metformin.

Mental health is tightly interwoven with hormonal and metabolic health. B-complex vitamins (especially B6 and B12) are involved in methylation, neurotransmitter synthesis (like serotonin and dopamine), and homocysteine metabolism. Low levels are linked to:

• PMS/PMDD symptoms
• Low mood
• Cognitive decline with aging

Hormone Balance includes bioavailable vitamins B6, B12 , and folate (B9) at clinically-supported doses to address these pathways.

Over 50% of adult women in the U.S. have either hypertension or pre-hypertension. Yet this is rarely addressed in “hormone support” supplements. Semaine takes a different approach.

• Grape seed extract has been shown to support healthy blood pressure, especially in people with metabolic dysfunction.
• By improving vascular tone and reducing inflammation, it indirectly supports mood, cognition, and skin health.

Hormonal health is sensitive to stress, but that doesn’t just mean emotional overwhelm. Stress hormones like cortisol, if chronically elevated, can dysregulate blood sugar, impair sleep, and suppress sex hormone production.

• Magnesium plays a central role in HPA axis modulation, muscle relaxation, and sleep regulation.
• Passionflower, a nervine botanical, has anxiolytic effects and helps downregulate sympathetic arousal, supporting better sleep and emotional stability.

Hormone Balance isn’t a pharmaceutical. It doesn’t override your body’s signals, it supports them. It also doesn’t promise miracles. But for many, it provides the foundation their body has been missing. By targeting root drivers like insulin resistance, inflammation, and nutritional gaps, it becomes easier for your hormones, sex, stress, metabolic, and more, to regulate themselves.