Formula white paper
Urinary Tract Cleanse & Protect: the evidence behind the formula
This page is a condensed, citation-preserving summary; the linked PDF is the complete document.
Executive summary
We designed Urinary Tract Cleanse & Protect with standardized cranberry phytosome and hibiscus to support normal bladder and urinary-tract health.[1][4] Cranberry phytosome may help reduce recurrent UTIs.[1][4]
Our current evidence includes a five-month consumer perception study of 48 women aged 40 and older and a 2024 randomized controlled trial of 120 mg daily cranberry phytosome in a high-risk population.[1][5]
Formulation rationale
Why we chose cranberry and hibiscus
We selected a standardized cranberry preparation because cranberry extracts vary in quality and cranberry polyphenols have been studied for microbial adhesion, biofilms, and urinary-tract health.[4][2] We selected hibiscus for its traditional use and published plant-extract research related to normal urinary composition and stone-forming processes.[3] These are composition and structure/function rationales, not claims to prevent or treat an infection.
Formula at a glance
Published literature
The evidence we used
Our review spans randomized, mechanistic, post-catheterization, systematic-review, and current consumer-perception evidence; it does not establish a finished-product treatment effect.[1][2][3][4][5]
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Risk contextEpidemiology
Urinary-tract risk differs by sex and changes across the lifespan.[1]
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Bladder epitheliumMechanistic review
The bladder epithelium participates in multiple antibacterial defenses, including shedding.[2]
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CranberryMeta-analysis
A meta-analysis evaluated cranberry consumption and recurrent urinary events in otherwise healthy women.[4]
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Clinical guidanceGuideline
The cited urology guideline reviews non-antibiotic options while emphasizing clinical management.[4]
Finished-formula evidence
Our current study context
In our five-month consumer perception study of 48 women aged 40 and older, 89% reported improvement in urinary environment and 89% reported improvement in bladder comfort.[5] These reported changes over time do not establish causation.[5]
In a 2024 RCT published in Nutrients, 120 mg of cranberry phytosome daily significantly modulated urinary-tract episode frequency versus placebo in postmenopausal women with type 2 diabetes taking SGLT-2 inhibitors.[1] This ingredient study does not establish that the finished product treats or prevents infection.[1]
Funding disclosure: No Semaine-funded finished-formula study is reported in the supplied v6 white paper.
Published research
- Rondanelli et al. Cranberry phytosome and urinary tract episodes in diabetic postmenopausal women on SGLT-2 inhibitors: a RCT. Nutrients (2024).Human clinical
- Baron et al. Cranberry components and metabolites in human urine. Biochemical Pharmacology (2020).Mechanism
- Cotellese et al. Anthocran Phytosome after catheterization. Journal of Dietary Supplements (2021).Human clinical
- Fu et al. Cranberry and urinary tract health in healthy women: a systematic review and meta-analysis. Journal of Nutrition (2017).Systematic review
- Semaine Health. Urinary Tract Cleanse & Protect current evidence page. Five-month consumer perception study of 48 women aged 40 and older.Consumer perception
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
